Description

4'-Bromo-3-(4-Chlorophenyl)-2'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated aromatic structure. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent neuroactive compounds and other specialized APIs.
• Drug Discovery Research: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) in new chemical entities.
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	4'-Bromo-3-(4-Chlorophenyl)-2'-Fluoropropiophenone
CAS No.	898788-31-3
Molecular Formula	C15H11BrClFO
Molecular Weight	356.60 g/mol
Synonyms	2'-Fluoro-4'-bromo-3-(4-chlorophenyl)propiophenone; 1-(4-Bromo-2-fluorophenyl)-3-(4-chlorophenyl)propan-1-one; 3-(4-Chlorophenyl)-1-(4-bromo-2-fluorophenyl)propan-1-one; 898788-31-3; 4'-Bromo-2'-fluoro-3-(4-chlorophenyl)propiophenone; Propiophenone, 4'-bromo-3-(4-chlorophenyl)-2'-fluoro-
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3-(4-Chlorophenyl)-2'-Fluoropropiophenone is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.