Description

3-(4-Acetoxyphenyl)-1,1,1-Trifluoro-2-Propanone is a high-purity fluorinated aromatic ketone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the trifluoromethyl ketone moiety, which is a versatile building block for introducing fluorine atoms into target molecules, thereby enhancing their metabolic stability, lipophilicity, and bioavailability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and pesticides with improved environmental and biological profiles.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Organic Synthesis Reagent: Acts as a versatile trifluoromethylating agent or a scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in R&D and production labs.

Basic Information

Product Name	3-(4-Acetoxyphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-80-9
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	1-[4-(Acetyloxy)phenyl]-3,3,3-trifluoro-2-propanone; 4'-Acetoxy-3,3,3-trifluoropropiophenone; 3,3,3-Trifluoro-1-(4-hydroxyphenyl)-2-propanone acetate; 1-(4-Acetoxyphenyl)-3,3,3-trifluoropropan-2-one; TFAP; Trifluoroacetophenone derivative
EINECS	Contact for details

Quality Control

Our 3-(4-Acetoxyphenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.