Description

3'-Acetoxy-2,2,2-trifluoroacetophenone is a specialized fluorinated aromatic ketone derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both a trifluoroacetyl and an acetoxy group, makes it a critical building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, particularly in medicinal chemistry research for CNS and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with unique surface properties.
• Liquid Crystal & OLED Research: Acts as a fluorinated core structure in the design of organic electronic materials for displays and lighting applications.
• Chemical Biology Probe Development: Utilized to create fluorinated analogs of natural products or biochemical probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic routes.

Basic Information

Product Name	3'-Acetoxy-2,2,2-trifluoroacetophenone
CAS No.	898787-73-0
Molecular Formula	C10H7F3O3
Molecular Weight	232.16 g/mol
Synonyms	1-[3-(Acetyloxy)phenyl]-2,2,2-trifluoroethanone; 3-Acetoxy-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3-hydroxyphenyl)ethanone acetate; 3'-Hydroxy-2,2,2-trifluoroacetophenone acetate; 3-Acetoxy-α,α,α-trifluoroacetophenone; 1-(3-Acetoxyphenyl)-2,2,2-trifluoroethanone; TFAP-OAc; 3-AcO-TFAP
EINECS	Contact for details

Quality Control

Our 3'-Acetoxy-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Standard quality control includes identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.