Description

1-(3-Chloro-4-Methylphenyl)-3,3,3-Trifluoro-2-Propanone is a high-purity trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both a chloromethylphenyl group and a reactive trifluoroacetyl moiety, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chiral ligands and catalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and introducing fluorine atoms into complex molecular architectures.

Basic Information

Product Name	1-(3-Chloro-4-Methylphenyl)-3,3,3-Trifluoro-2-Propanone
CAS No.	898787-71-8
Molecular Formula	C10H8ClF3O
Molecular Weight	236.62 g/mol
Synonyms	3'-Chloro-4'-Methyl-2,2,2-Trifluoroacetophenone; 2,2,2-Trifluoro-1-(3-chloro-4-methylphenyl)ethanone; 1-(3-Chloro-4-methylphenyl)-2,2,2-trifluoroethanone; 3-Chloro-4-methyl-α,α,α-trifluoroacetophenone; TFAP derivative; Trifluoromethyl Ketone Intermediate; (3-Chloro-4-methylphenyl) trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-4-Methylphenyl)-3,3,3-Trifluoro-2-Propanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.