Description

3-(2-Iodophenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated and iodinated aromatic ketone building block. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, where it serves as a versatile intermediate for constructing trifluoromethylated and aryl-iodinated scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around fluorinated aromatic systems.
• Agrochemical Synthesis: Intermediate for developing novel herbicides, fungicides, and insecticides that leverage the properties of fluorine and iodine atoms.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Material Science Precursor: Potential starting material for synthesizing specialized fluorinated organic materials and ligands for catalysis.

Basic Information

Product Name	3-(2-Iodophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-65-0
Molecular Formula	C9H6F3IO
Molecular Weight	314.04 g/mol
Synonyms	1-(2-Iodophenyl)-3,3,3-trifluoropropan-1-one; 2'-Iodo-3,3,3-trifluoropropiophenone; α,α,α-Trifluoro-2'-iodopropiophenone; 3,3,3-Trifluoro-1-(2-iodophenyl)propan-1-one; 2-Iodophenyl trifluoromethyl ketone; TFIP-I; Iodo-trifluoropropiophenone
EINECS	Contact for details

Quality Control

We supply 3-(2-Iodophenyl)-1,1,1-Trifluoro-2-Propanone in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.