Description

3-(2,5-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block essential for advanced organic synthesis. Its unique structure, featuring a difluorophenyl ring and a trifluoroacetyl group, makes it a critical intermediate for introducing specific fluorine patterns into target molecules, which is vital for modulating the physical, chemical, and biological properties of final compounds. This product is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in developing next-generation herbicides, fungicides, and insecticides, where the difluorophenyl moiety contributes to improved pesticidal activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies, where fluorine atoms help fine-tune dielectric anisotropy and improve device performance.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with enhanced chemical resistance, thermal stability, and optical properties for high-performance coatings and engineering plastics.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed reactions, such as the Heck or Suzuki reactions, for constructing complex biaryl systems.
• Fluorine Chemistry Research: A valuable reference standard and starting material in academic and industrial laboratories focused on exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	3-(2,5-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-51-4
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1,1,1-Trifluoro-3-(2,5-difluorophenyl)propan-2-one; 2',5'-Difluoro-3,3,3-trifluoropropiophenone; 2,5-Difluoro-β,β,β-trifluoropropiophenone; 3,3,3-Trifluoro-1-(2,5-difluorophenyl)propan-1-one; 898787-51-4; 3-(2,5-Difluorophenyl)-1,1,1-trifluoropropan-2-one; 1-(2,5-Difluorophenyl)-3,3,3-trifluoro-1-propanone
EINECS	Contact for details

Quality Control

Our 3-(2,5-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 19F NMR)
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.