Description

3-(3-Chlorophenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular scaffold, which combines a chlorophenyl group with a trifluorinated propiophenone moiety, enabling precise structural modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Serves as a critical building block for developing new-generation herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where the fluorine atoms impart desirable thermal and chemical stability.
• Organic Synthesis: An essential fluorinated synthon for Suzuki-Miyaura and other cross-coupling reactions to construct complex biaryl systems.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-(3-Chlorophenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898787-48-9
Molecular Formula	C15H9ClF3O
Molecular Weight	304.68 g/mol
Synonyms	1-(3-Chlorophenyl)-3-(3,4,5-trifluorophenyl)propan-1-one; 3',4',5'-Trifluoro-3-chloropropiophenone; 3-Chloro-3',4',5'-trifluoropropiophenone; 3-(3-Chlorophenyl)-1-(3,4,5-trifluorophenyl)propan-1-one; Propiophenone, 3-(3-chlorophenyl)-3',4',5'-trifluoro-; 898787-48-9 (CAS Name)
EINECS	Contact for details

Quality Control

Our 3-(3-Chlorophenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to minimize moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.