Description

3-(3,4-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone is a high-purity fluorinated aromatic ketone building block. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, valued for its ability to introduce both difluorophenyl and trifluoromethyl motifs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging the stability and bioavailability imparted by the fluorine atoms.
• Material Science Precursor: Serves as a building block for fluorinated polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Life Science Research: Used as a biochemical tool and probe in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	3-(3,4-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-47-8
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3,3,3-trifluoropropan-1-one; 3,3,3-Trifluoro-1-(3,4-difluorophenyl)-1-propanone; 3,4-Difluoro-ω,ω,ω-trifluoroacetophenone; 3,4-Difluorophenyl trifluoroethyl ketone; 898787-47-8; 3-(3,4-Difluorophenyl)-1,1,1-trifluoropropan-2-one (common misnomer); DFTP
EINECS	Contact for details

Quality Control

Our 3-(3,4-Difluorophenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, organic solvents, and strong bases/fluorides. The container should be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.