Description

3'-Chloro-3-(3-Chlorophenyl)-5'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its unique scaffold enables precise molecular modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for investigations into new organic synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	3'-Chloro-3-(3-Chlorophenyl)-5'-Fluoropropiophenone
CAS No.	898787-33-2
Molecular Formula	C15H11Cl2FO
Molecular Weight	297.15 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(3-chlorophenyl)propan-1-one; 3-Chloro-3-(3-chlorophenyl)-5'-fluoropropiophenone; 3'-Chloro-5'-fluoro-3-(3-chlorophenyl)propiophenone; 898787-33-2; 3-(3-Chlorophenyl)-1-(3-chloro-5-fluorophenyl)propan-1-one; Propiophenone, 3'-chloro-3-(3-chlorophenyl)-5'-fluoro-
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(3-Chlorophenyl)-5'-Fluoroprophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.