Description

4'-Carboethoxy-2,2,2-Trifluoroacetophenone is a high-value, multi-functional organic intermediate characterized by its trifluoromethyl and ester functional groups. This compound is critical for the synthesis of advanced pharmaceutical ingredients and agrochemicals, where its unique structure imparts desirable metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl motifs for enhanced bioactivity and stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers and organic electronic materials with unique properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4'-Carboethoxy-2,2,2-Trifluoroacetophenone
CAS No.	898787-14-9
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	Ethyl 4-(2,2,2-trifluoroacetyl)benzoate; 4-(Ethoxycarbonyl)-2,2,2-trifluoroacetophenone; 4-Carbethoxy-α,α,α-trifluoroacetophenone; 4-(Trifluoroacetyl)benzoic Acid Ethyl Ester; Ethyl 4-(Trifluoroacetyl)benzoate; 2,2,2-Trifluoro-1-[4-(ethoxycarbonyl)phenyl]ethanone; TFAP-ester; 898787-14-9
EINECS	Contact for details

Quality Control

Our 4'-Carboethoxy-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.