Description

3',5'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a high-value fluorinated organic intermediate featuring a protected carbonyl group. This compound matters for its role as a critical building block in the synthesis of complex pharmaceutical molecules, particularly those requiring specific fluorine substitution patterns. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) with fluorinated aromatic systems, potentially for CNS, anti-inflammatory, or metabolic disease targets.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, or pesticides where the difluoro and protected ketone functionalities impart desired biological activity and metabolic stability.
• Ligand and Catalyst Development: Used in research for creating specialized ligands or organocatalysts in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing fluorinated monomers or polymers aimed at creating materials with unique surface properties, chemical resistance, or optical characteristics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects at various scales.
• Academic and Industrial R&D: Serves as a versatile starting material in exploratory chemistry for drug discovery and method development in organic synthesis laboratories.

Basic Information

Product Name	3',5'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898787-02-5
Molecular Formula	C₁₆H₂₀F₂O₃
Molecular Weight	298.33 g/mol
Synonyms	1-[3,5-Difluoro-4-[2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl]phenyl]ethanone; 3,5-Difluoro-4'-(5,5-dimethyl-1,3-dioxan-2-yl)butyrophenone; 2-[4-Acetyl-2,6-difluorophenethyl]-5,5-dimethyl-1,3-dioxane; Butyrophenone, 3',5'-difluoro-4-(5,5-dimethyl-1,3-dioxan-2-yl)-; Difluoro Dimethyl Dioxanyl Butyrophenone
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.