Description

3',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated aromatic ketone structure fused with a dioxane acetal protecting group. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders. It is primarily needed by research institutions, custom synthesis houses, and large-scale pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• API Synthesis: Used as a key building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Neurological Drug Development: Particularly relevant in the research and production of compounds targeting neurological pathways, given its structural features.
• Custom & Contract Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical synthesis projects.
• Process Chemistry & Scale-Up: Utilized in process optimization and scaling from laboratory to pilot plant and commercial production.
• Chemical Research: Acts as a specialized reagent for exploring new fluorination reactions and protecting group strategies in organic synthesis.

Basic Information

Product Name	3',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898786-97-5
Molecular Formula	C₁₆H₂₀F₂O₃
Molecular Weight	298.33 g/mol
Synonyms	4-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(3,4-difluorophenyl)butan-1-one; 1-(3,4-Difluorophenyl)-4-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one; 3,4-Difluoro-4'-(5,5-dimethyl-1,3-dioxan-2-yl)butyrophenone; DF-DDB; Butyrophenone, 3',4'-difluoro-4-(5,5-dimethyl-1,3-dioxan-2-yl)-; Acetal-protected difluorobutyrophenone derivative
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.