Description

2',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique dioxane-protected ketone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of fluorinated drug candidates, where it serves as a key building block for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex fluorinated active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing novel heterocyclic compounds and exploring new synthetic methodologies.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation fluorinated pesticides and herbicides.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic materials requiring specific fluorine-containing motifs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898786-83-9
Molecular Formula	C₁₆H₂₀F₂O₃
Molecular Weight	298.33 g/mol
Synonyms	4-(5,5-Dimethyl-1,3-dioxan-2-yl)-2',4'-difluorobutyrophenone; 2',4'-Difluoro-4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-butanone; 1-(2,4-Difluorophenyl)-4-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one; DFDB; Dioxane-protected difluorobutyrophenone intermediate
EINECS	Contact for details

Quality Control

Every batch of 2',4'-Difluoro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.