Description

3'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique dioxane-protected ketone structure. This compound is critical for the synthesis of complex organic molecules, offering a versatile building block for medicinal chemistry research and process development. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical and fine chemical industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value specialty chemicals for agrochemical and material science applications.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898785-88-1
Molecular Formula	C₁₆H₂₁ClO₃
Molecular Weight	296.79 g/mol
Synonyms	2-[4-(3-Chlorophenyl)-4-oxobutyl]-5,5-dimethyl-1,3-dioxane; 3'-Chloro-4'-(5,5-dimethyl-1,3-dioxan-2-yl)butyrophenone; 4-(3-Chlorophenyl)-1-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one; 898785-88-1; Butyrophenone, 3'-chloro-4-(5,5-dimethyl-1,3-dioxan-2-yl)-; 3-Chloro-4'-(5,5-dimethyl-1,3-dioxan-2-yl)butyrophenone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards. Our commitment to cGMP principles ensures reliability for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.