Description

2-(3-Fluorophenyl)-3'-Iodoacetophenone is a high-purity, specialized organic building block featuring both fluorinated and iodinated aromatic systems. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecular architectures via cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use as a key intermediate in the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine and iodine substituents can modulate biological activity and environmental stability.
• Material Science: Serves as a building block for advanced organic materials, such as liquid crystals and organic semiconductors, where its specific halogen pattern influences electronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, enabling efficient carbon-carbon bond formation.
• Medicinal Chemistry Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Chemical Biology Probes: Used to create labeled molecules or probes for studying biological pathways and protein interactions.

Basic Information

Product Name	2-(3-Fluorophenyl)-3'-Iodoacetophenone
CAS No.	898784-79-7
Molecular Formula	C14H10FIO
Molecular Weight	340.13 g/mol
Synonyms	3'-Iodo-2-(3-fluorophenyl)acetophenone; 1-[3-Iodophenyl]-2-(3-fluorophenyl)ethanone; 2-(3-Fluorophenyl)-1-(3-iodophenyl)ethan-1-one; 3-Iodophenyl 3-fluorobenzyl ketone; (3-Iodophenyl)(3-fluorophenyl)methanone (tautomeric form); 898784-79-7; 3'-Iodo-3-fluoro deoxybenzoin
EINECS	Contact for details

Quality Control

Our 2-(3-Fluorophenyl)-3'-Iodoacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with the standards required for research and cGMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.