Description

2-(2-Fluorophenyl)-2'-Iodoacetophenone is a high-value, multi-functional aromatic ketone building block featuring both fluorine and iodine substituents. This compound is critical for advanced organic synthesis, offering versatile reactivity for cross-coupling reactions and serving as a key precursor in complex molecular construction. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine and iodine groups contribute to biological activity and metabolic stability.
• Ligand & Catalyst Synthesis: Acts as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Precursor: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system and halogen atoms.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form complex biaryl structures.
• Fluorine Chemistry Studies: Used as a model compound in research exploring the effects of ortho-fluorine substitution on reaction kinetics and molecular conformation.

Basic Information

Product Name	2-(2-Fluorophenyl)-2'-Iodoacetophenone
CAS No.	898784-73-1
Molecular Formula	C14H10FIO
Molecular Weight	340.13 g/mol
Synonyms	2'-Iodo-2-(2-fluorophenyl)acetophenone; 1-(2-Iodophenyl)-2-(2-fluorophenyl)ethan-1-one; 2-Fluorophenyl 2'-iodophenyl ketone; α-(2-Fluorophenyl)-o-iodoacetophenone; (2-Iodophenyl)(2-fluorophenyl)methanone; 2-(2-Fluorobenzyl)-2'-iodobenzophenone (common misnomer); FIPK-I (abbrev.); 898784-73-1
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Fluorophenyl)-2'-Iodoacetophenone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive characterization by NMR (1H, 13C), HPLC, and GC-MS to verify structure and assay purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric contaminants. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.