Description

2-(2-Cyanophenyl)-4'-Trifluoromethylacetophenone is a specialized organic building block featuring both cyano and trifluoromethyl functional groups on a biphenyl ketone scaffold. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with specific electronic or optical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(2-Cyanophenyl)-4'-Trifluoromethylacetophenone
CAS No.	898784-49-1
Molecular Formula	C16H10F3NO
Molecular Weight	289.26 g/mol
Synonyms	2-(2-Cyanophenyl)-1-[4-(trifluoromethyl)phenyl]ethanone; 1-[4-(Trifluoromethyl)phenyl]-2-(2-cyanophenyl)ethanone; 2-Cyanophenyl 4-(Trifluoromethyl)phenyl Ketone; α-(2-Cyanophenyl)-4'-(trifluoromethyl)acetophenone; 2-(2-Cyanophenyl)-4'-trifluoromethyl acetophenone; [4-(Trifluoromethyl)phenyl][2-(cyanophenyl)]methanone derivative
EINECS	Contact for details

Quality Control

Our 2-(2-Cyanophenyl)-4'-Trifluoromethylacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for residual solvent analysis, to ensure it meets the stringent requirements of advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.