Description

2-(3-Bromophenyl)-4'-Trifluoromethylacetophenone is a high-purity, specialized organic building block featuring a bromophenyl and a trifluoromethylacetophenone moiety. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecular architectures in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life science industries for applications in cross-coupling reactions and as a key intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or inflammatory diseases.
• Agrochemical Research: Serves as a key precursor in the development of new herbicides, fungicides, or insecticides, leveraging the biological activity of the trifluoromethyl group.
• Material Science: Used in the research and development of advanced organic materials, such as liquid crystals or organic semiconductors, where its specific aromatic and halogenated structure can tune electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical and agrochemical sectors.

Basic Information

Product Name	2-(3-Bromophenyl)-4'-Trifluoromethylacetophenone
CAS No.	898784-21-9
Molecular Formula	C15H10BrF3O
Molecular Weight	343.14 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-2-(3-bromophenyl)ethanone; 2-(3-Bromophenyl)-1-[4-(trifluoromethyl)phenyl]ethan-1-one; 3'-Bromo-4'-(trifluoromethyl) desoxybenzoin; α-(3-Bromophenyl)-4'-(trifluoromethyl)acetophenone; (3-Bromophenyl)[4-(trifluoromethyl)phenyl]methanone (tautomeric form); 898784-21-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-(3-Bromophenyl)-4'-Trifluoromethylacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.