Description

2-Phenyl-2'-Trifluoromethylacetophenone is a specialized aromatic ketone derivative featuring a trifluoromethyl substituent, a structural motif of significant interest in advanced organic synthesis. This compound serves as a versatile and high-value pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated aromatic systems into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) in asymmetric catalysis.
• Material Science Research: Intermediate for creating fluorinated polymers or liquid crystals with unique optical and electronic properties.
• Chemical Biology Probes: Utilized in the design of fluorinated probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring bespoke fluorinated aromatic compounds.

Basic Information

Product Name	2-Phenyl-2'-Trifluoromethylacetophenone
CAS No.	898783-80-7
Molecular Formula	C15H11F3O
Molecular Weight	264.24 g/mol
Synonyms	2-Phenyl-1-[2-(trifluoromethyl)phenyl]ethanone; 1-[2-(Trifluoromethyl)phenyl]-2-phenylethanone; 2-Phenyl-2'-(trifluoromethyl)acetophenone; α-Phenyl-2'-(trifluoromethyl)acetophenone; 2-(Trifluoromethyl)desoxybenzoin; TFMPA; 2-Phenyl-1-(2-trifluoromethylphenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our production of 2-Phenyl-2'-Trifluoromethylacetophenone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.