Description

2'-Thiomorpholinomethyl-3,4,5-Trifluorobenzophenone is a high-value, fluorinated benzophenone derivative featuring a thiomorpholine moiety. This compound is a critical advanced pharmaceutical intermediate (API intermediate) used in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• CNS Drug Development: Used in research and production of potential therapeutics for neurological conditions, leveraging the structural properties of the thiomorpholine and benzophenone groups.
• Kinase Inhibitor Synthesis: Serves as a precursor in the creation of kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Custom Synthesis: Used by CDMOs for the contract manufacturing of specific, high-purity intermediates for client drug development pipelines.

Basic Information

Product Name	2'-Thiomorpholinomethyl-3,4,5-Trifluorobenzophenone
CAS No.	898782-50-8
Molecular Formula	C18H15F3NO2S
Molecular Weight	366.38 g/mol
Synonyms	2'-((Thiomorpholin-4-yl)methyl)-3,4,5-trifluorobenzophenone; 3,4,5-Trifluoro-2-(thiomorpholinomethyl)benzophenone; 2-(Thiomorpholin-4-ylmethyl)-3,4,5-trifluorobenzophenone; Benzophenone, 2-[(thiomorpholin-4-yl)methyl]-3,4,5-trifluoro-; 898782-50-8; 2-Thiomorpholin-4-ylmethyl-3,4,5-trifluorobenzophenone
EINECS	Contact for details

Quality Control

Our 2'-Thiomorpholinomethyl-3,4,5-Trifluorobenzophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.