Description

3-(4-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated organic intermediate featuring a unique trifluoropropiophenone core linked to a thiomethylphenyl group. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients, where its specific fluorine substitution pattern is essential for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Building block for developing next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Used in research for creating fluorinated components in liquid crystal mixtures for advanced display technologies.
• Organic Electronics: Serves as a starting material in the synthesis of specialized organic semiconductors and charge-transport materials.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and material science exploration due to its reactive ketone and sulfide functionalities.
• Custom Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development projects.

Basic Information

Product Name	3-(4-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898781-83-4
Molecular Formula	C₁₆H₁₁F₃OS
Molecular Weight	308.32 g/mol
Synonyms	1-[3-(4-Methylthio)phenyl]-3-(3,4,5-trifluorophenyl)propan-1-one; 3',4',5'-Trifluoro-3-(4-(methylthio)phenyl)propiophenone; 3-(4-Methylsulfanylphenyl)-3',4',5'-trifluoropropiophenone; 898781-83-4; Propiophenone, 3-(4-(methylthio)phenyl)-3',4',5'-trifluoro-; CAS 898781-83-4
EINECS	Contact for details

Quality Control

Our 3-(4-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring GMP-grade materials for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.