Description

3',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoro and thiomethylphenyl substitution pattern. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise molecular architecture is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially in medicinal chemistry research and development.
• API Synthesis: Used as a core scaffold for constructing complex molecules with potential antipsychotic, antidepressant, or anti-inflammatory properties.
• Chemical Research: Serves as a valuable reference standard and starting material in academic and industrial laboratories for studying structure-activity relationships (SAR).
• Process Development: Employed in scaling up and optimizing synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	3',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone
CAS No.	898781-79-8
Molecular Formula	C16H14F2OS
Molecular Weight	292.34 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3-[4-(methylthio)phenyl]propan-1-one; 3-(4-Methylsulfanylphenyl)-1-(3,4-difluorophenyl)propan-1-one; 3',4'-Difluoro-3-(4-methylthiophenyl)propiophenone; 3-(4-Methylmercaptophenyl)-1-(3,4-difluorophenyl)-1-propanone; Propiophenone, 3',4'-difluoro-3-(4-(methylthio)phenyl)-; CAS 898781-79-8
EINECS	Contact for details

Quality Control

Our production of 3',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.