Description

2',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct difluoro and thiomethylphenyl substitution pattern. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new drug candidates and proprietary synthetic routes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, fluorinated active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex molecules, leveraging its fluorine atoms for modulating bioactivity and physicochemical properties.
• Agrochemical Development: Serves as a precursor in the research and production of advanced crop protection agents and pesticides.
• Material Science: Investigated for the development of specialty polymers and advanced organic materials with specific electronic or structural characteristics.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone
CAS No.	898781-77-6
Molecular Formula	C16H14F2OS
Molecular Weight	292.34 g/mol
Synonyms	3-(4-(Methylthio)phenyl)-2',4'-difluoropropiophenone; 1-(2,4-Difluorophenyl)-3-[4-(methylsulfanyl)phenyl]propan-1-one; 2',4'-Difluoro-3-(4-methylthiophenyl)propiophenone; 898781-77-6; Propiophenone, 2',4'-difluoro-3-(4-(methylthio)phenyl)-; 3-(4-Methylsulfanylphenyl)-2',4'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-3-(4-Thiomethylphenyl)Propiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, GC, and NMR spectra, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is supplied with each shipment, and we support compliance with relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.