Description

3'-Chloro-4'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated and thiomethyl-substituted aromatic structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular frameworks. It is primarily utilized by research institutions and manufacturers in the global pharmaceutical and fine chemical industries engaged in developing new drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of novel APIs, especially in oncology and central nervous system (CNS) drug research.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Precursor for Agrochemicals: Potential application in the synthesis of advanced herbicides and pesticides, leveraging its halogenated aromatic core.
• Material Science Applications: Investigated as a monomer or precursor for specialty polymers and liquid crystals due to its rigid, substituted biphenyl-like structure.

Basic Information

Product Name	3'-Chloro-4'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone
CAS No.	898781-45-8
Molecular Formula	C16H14ClFOS
Molecular Weight	308.80 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-[4-(methylthio)phenyl]propan-1-one; 3-(4-Methylthiophenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one; 3'-Chloro-4'-fluoro-3-(4-methylmercaptophenyl)propiophenone; 898781-45-8; Propiophenone, 3'-chloro-4'-fluoro-3-(4-(methylthio)phenyl)-; 1-(3-Chloro-4-fluorophenyl)-3-(4-methylsulfanylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our production of 3'-Chloro-4'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and regulatory compliance ensures a reliable supply for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.