Description

4'-Bromo-3'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated aromatic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D and manufacturing teams need this precise intermediate to ensure the fidelity and efficiency of their multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel small-molecule drug candidates, especially in neurological and metabolic disease research.
• API Synthesis: Serves as a key building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in scaling up synthetic pathways from laboratory to pilot plant and commercial production.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke intermediates.
• Academic Research: Utilized in university and institutional labs for developing new synthetic methodologies and exploring heterocyclic chemistry.

Basic Information

Product Name	4'-Bromo-3'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone
CAS No.	898781-39-0
Molecular Formula	C₁₆H₁₄BrFOS
Molecular Weight	353.25 g/mol
Synonyms	1-(4-Bromo-3-fluorophenyl)-3-[4-(methylthio)phenyl]propan-1-one; 3-(4-Methylthiophenyl)-1-(4-bromo-3-fluorophenyl)propan-1-one; 4'-Bromo-3'-fluoro-3-(4-methylthiophenyl)propiophenone; 898781-39-0; Propiophenone, 4'-bromo-3'-fluoro-3-(4-(methylthio)phenyl)-; 1-(4-Bromo-3-fluorophenyl)-3-(4-methylsulfanylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3'-Fluoro-3-(4-Thiomethylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.