Description

2'-Chloro-3-(3,5-Dimethylphenyl)-4'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally defined building block essential for research and development in modern medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry Development: Serves as a standard reference material for scaling up and validating synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Institutional R&D: Employed in university and research institute laboratories for investigating new organic reactions and synthetic methodologies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and process optimization.

Basic Information

Product Name	2'-Chloro-3-(3,5-Dimethylphenyl)-4'-Fluoropropiophenone
CAS No.	898780-92-2
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)-3-(3,5-dimethylphenyl)propan-1-one; 2'-Chloro-4'-fluoro-3-(3,5-dimethylphenyl)propiophenone; 3-(3,5-Dimethylphenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 898780-92-2; Propiophenone, 2'-chloro-3-(3,5-dimethylphenyl)-4'-fluoro-; 2-Chloro-4-fluoro-β-(3,5-dimethylbenzyl)propiophenone
EINECS	Contact for details

Quality Control

Our 2'-Chloro-3-(3,5-Dimethylphenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical development and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.