Description

3-(2-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone derivative, serving as a critical advanced pharmaceutical intermediate (API). Its value lies in its unique trifluoromethyl and thiomethyl functional groups, which are essential for modulating the biological activity, metabolic stability, and lipophilicity of target drug molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers and liquid crystals with tailored optical and electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a scaffold for constructing complex heterocyclic compounds in academic and industrial laboratories.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorination on molecular properties.

Basic Information

Product Name	3-(2-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898780-63-7
Molecular Formula	C₁₆H₁₃F₃OS
Molecular Weight	310.34 g/mol
Synonyms	1-[3-(Methylthio)phenyl]-3',4',5'-trifluoropropiophenone; 3',4',5'-Trifluoro-3-[(2-methylthio)phenyl]propiophenone; 3-(2-Methylthiophenyl)-3',4',5'-trifluoropropiophenone; 3-(2-(Methylthio)phenyl)-1-(3,4,5-trifluorophenyl)propan-1-one; Propiophenone, 3-(2-(methylthio)phenyl)-3',4',5'-trifluoro-; CAS 898780-63-7
EINECS	Contact for details

Quality Control

Our 3-(2-Thiomethylphenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.