Description

4'-Chloro-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone is a high-value, multi-functional organic intermediate characterized by its unique halogenated and sulfur-containing aromatic structure. This compound matters for its critical role in the synthesis of complex, biologically active molecules, offering chemists precise points for further functionalization. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen and sulfur motifs for enhanced bioactivity.
• Material Science Research: Serves as a precursor for advanced organic materials, including liquid crystals and functional polymers, where its aromatic and thioether groups contribute to desired electronic or structural properties.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone
CAS No.	898780-40-0
Molecular Formula	C16H14ClFOS
Molecular Weight	308.80 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-[2-(methylthio)phenyl]propan-1-one; 3-(2-Methylthiophenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 4'-Chloro-2'-fluoro-3-(2-methylthiophenyl)propiophenone; 898780-40-0; 4-Chloro-2-fluoro-3'-(methylthio)propiophenone; Propiophenone, 4'-chloro-2'-fluoro-3-(2-(methylthio)phenyl)-
EINECS	Contact for details

Quality Control

Our production of 4'-Chloro-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We support development and commercial projects with material produced under a quality system designed to meet the demands of cGMP and ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.