Description

3'-Chloro-5'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone is a high-value, multi-functional organic intermediate characterized by its distinct halogenated and sulfur-containing aromatic structure. This compound matters for its critical role in the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to build novel molecular scaffolds with specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen and sulfur motifs for bioactivity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its conjugated system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	3'-Chloro-5'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone
CAS No.	898780-37-5
Molecular Formula	C16H14ClFOS
Molecular Weight	308.80 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-[2-(methylthio)phenyl]propan-1-one; 3'-Chloro-5'-fluoro-3-(2-methylthiophenyl)propiophenone; 898780-37-5; Propiophenone, 3'-chloro-5'-fluoro-3-(2-(methylthio)phenyl)-; 1-(3-Chloro-5-fluorophenyl)-3-(2-methylsulfanylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3'-Chloro-5'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.