Description

4'-Bromo-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone CAS NO 898780-31-9 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated and sulfur-containing aromatic structure. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• API Synthesis: Used in the construction of complex molecular scaffolds for potential antipsychotic, antidepressant, or neuroprotective agents.
• Chemical Research & Development: Employed in academic and industrial R&D labs for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Process Chemistry: Integral for scaling up and optimizing synthetic routes from laboratory to pilot plant and commercial production scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	4'-Bromo-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone
CAS No.	898780-31-9
Molecular Formula	C₁₆H₁₄BrFOS
Molecular Weight	353.25 g/mol
Synonyms	1-(4-Bromo-2-fluorophenyl)-3-[2-(methylthio)phenyl]propan-1-one; 3-(2-Methylthiophenyl)-1-(4-bromo-2-fluorophenyl)propan-1-one; 4'-Bromo-2'-fluoro-3-(2-methylthiophenyl)propiophenone; 898780-31-9; 4'-Bromo-2'-fluoro-3-(2-(methylthio)phenyl)propiophenone; 1-(4-Bromo-2-fluorophenyl)-3-(2-methylsulfanylphenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2'-Fluoro-3-(2-Thiomethylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.