Description

2',4'-Difluoro-3-(3,4-Dimethylphenyl)Propiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where its unique difluoro-dimethylphenyl structure imparts specific biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorinated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent development.
• Agrochemical Synthesis: Serves as a precursor for advanced herbicides and fungicides, leveraging the fluorine atoms to enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic & Contract Research: Utilized in university and CRO settings for methodological studies in fluorination chemistry and asymmetric synthesis.

Basic Information

Product Name	2',4'-Difluoro-3-(3,4-Dimethylphenyl)Propiophenone
CAS No.	898779-85-6
Molecular Formula	C17H16F2O
Molecular Weight	274.31 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3-(3,4-dimethylphenyl)propan-1-one; 3-(3,4-Dimethylphenyl)-1-(2,4-difluorophenyl)propan-1-one; 2,4-Difluoro-3',4'-dimethylpropiophenone; 898779-85-6; Propiophenone, 2',4'-difluoro-3-(3,4-dimethylphenyl)-; 1-Propanone, 1-(2,4-difluorophenyl)-3-(3,4-dimethylphenyl)-
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-3-(3,4-Dimethylphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.