Description

4'-Chloro-3-(3,4-Dimethylphenyl)-2'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its unique molecular framework serves as a key building block. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and fine chemical sectors engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Organic Synthesis Reagent: Used in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to construct complex biaryl systems.
• Agrochemical Research: Serves as a precursor in the development of new generation herbicides and pesticides with tailored activity.
• Material Science: Potential monomer or additive in the synthesis of specialty polymers with specific optical or electronic properties.
• Academic & Contract Research: Employed in university and CRO settings for methodological development and exploration of new chemical spaces.

Basic Information

Product Name	4'-Chloro-3-(3,4-Dimethylphenyl)-2'-Fluoropropiophenone
CAS No.	898779-73-2
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	2'-Fluoro-4'-chloro-3-(3,4-dimethylphenyl)propiophenone; 1-(4-Chloro-2-fluorophenyl)-3-(3,4-dimethylphenyl)propan-1-one; 3-(3,4-Dimethylphenyl)-1-(2-fluoro-4-chlorophenyl)propan-1-one; 898779-73-2; 4'-Chloro-2'-fluoro-3-(3,4-dimethylphenyl)propiophenone; Propiophenone, 4'-chloro-3-(3,4-dimethylphenyl)-2'-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-3-(3,4-Dimethylphenyl)-2'-Fluoropropiophenone is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.