Description

3'-Chloro-3-(3,4-Dimethylphenyl)-4'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic agents and specialty chemicals. Consistent quality and reliable supply are paramount for its successful integration into multi-step synthetic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry research for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Organic Synthesis Research: Serves as a versatile precursor for creating complex molecules in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalytic systems in asymmetric synthesis.
• Material Science Precursor: Investigated for the development of organic electronic materials and specialty polymers.

Basic Information

Product Name	3'-Chloro-3-(3,4-Dimethylphenyl)-4'-Fluoropropiophenone
CAS No.	898779-55-0
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(3,4-dimethylphenyl)propan-1-one; 3-(3,4-Dimethylphenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one; 3'-Chloro-3-(3,4-dimethylphenyl)-4'-fluoropropiophenone; 898779-55-0; Propiophenone, 3'-chloro-3-(3,4-dimethylphenyl)-4'-fluoro-; 3-(3,4-Dimethylphenyl)-1-(3-chloro-4-fluorophenyl)-1-propanone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(3,4-Dimethylphenyl)-4'-Fluoropropiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.