Description

4-Bromo-3'-(1,3-Dioxolan-2-Yl)-3-Fluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated benzophenone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its specific bromo and fluoro substituents enable precise molecular modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, leveraging its halogenated aromatic system for bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the research of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis Reagent: Employed in organic synthesis for Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions due to the reactive bromine moiety.
• Academic & Institutional Research: A valuable compound for university and contract research organizations (CROs) studying fluorinated and heterocyclic chemistry.

Basic Information

Product Name	4-Bromo-3'-(1,3-Dioxolan-2-Yl)-3-Fluorobenzophenone
CAS No.	898779-48-1
Molecular Formula	C₁₆H₁₂BrFO₃
Molecular Weight	351.17 g/mol
Synonyms	4-Bromo-3'-(1,3-dioxolan-2-yl)-3-fluorobenzophenone; 3-Fluoro-4-bromo-3'-(1,3-dioxolan-2-yl)benzophenone; 2-[3-(4-Bromo-3-fluorobenzoyl)phenyl]-1,3-dioxolane; Benzophenone, 4-bromo-3'-(1,3-dioxolan-2-yl)-3-fluoro-; 898779-48-1
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-3'-(1,3-Dioxolan-2-Yl)-3-Fluorobenzophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods including HPLC, GC, and NMR. We operate under a cGMP-compliant quality system suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.