Description

2',4'-Difluoro-3-(3,4,5-Trifluorophenyl)Propiophenone is a high-value fluorinated aromatic ketone intermediate, distinguished by its unique polyfluorinated structure. This compound is critical for its role in synthesizing advanced pharmaceutical and agrochemical active ingredients, where its fluorine atoms impart enhanced metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging fluorine's ability to improve lipophilicity and target binding.
• Material Science Research: Serves as a precursor for fluorinated liquid crystals or organic electronic materials due to its stable aromatic core.
• Organic Synthesis Scaffold: Employed in cross-coupling reactions and carbonyl chemistry to create diverse chemical libraries for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	2',4'-Difluoro-3-(3,4,5-Trifluorophenyl)Propiophenone
CAS No.	898778-62-6
Molecular Formula	C15H8F5O
Molecular Weight	308.22 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3-(3,4,5-trifluorophenyl)propan-1-one; 3-(3,4,5-Trifluorophenyl)-1-(2,4-difluorophenyl)propan-1-one; 2,4-Difluoro-3',4',5'-trifluoropropiophenone; Propiophenone, 2',4'-difluoro-3-(3,4,5-trifluorophenyl)-; 898778-62-6; 2,4-Difluoro-β-(3,4,5-trifluorophenyl)propiophenone
EINECS	Contact for details

Quality Control

Every batch of 2',4'-Difluoro-3-(3,4,5-Trifluorophenyl)Propiophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and MS to ensure identity and consistency. A Certificate of Analysis (COA) is supplied with each shipment, and we support audits and regulatory documentation for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.