Description

2',5'-Dichloro-3-(3,4,5-trifluorophenyl)propiophenone is a high-value, multi-halogenated aromatic ketone building block essential for advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen pattern enables precise molecular tuning. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, fluorinated target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Serves as a crucial precursor for developing next-generation herbicides and fungicides, leveraging the bioactivity of the trifluoromethylphenyl moiety.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where its structural rigidity and halogen content can modify material properties.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution for introducing complex aryl groups.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding structure-activity relationships (SAR) in fluorinated aromatic systems.

Basic Information

Product Name	2',5'-Dichloro-3-(3,4,5-trifluorophenyl)propiophenone
CAS No.	898778-56-8
Molecular Formula	C15H8Cl2F3O
Molecular Weight	341.13 g/mol
Synonyms	1-(2,5-Dichlorophenyl)-3-(3,4,5-trifluorophenyl)propan-1-one; 3-(3,4,5-Trifluorophenyl)-1-(2,5-dichlorophenyl)propan-1-one; 2,5-Dichloro-3'-(3,4,5-trifluorophenyl)propiophenone; 2',5'-Dichloro-3-(3,4,5-trifluorophenyl)propiophenone; Propiophenone, 2',5'-dichloro-3-(3,4,5-trifluorophenyl)-; 898778-56-8
EINECS	Contact for details

Quality Control

Our 2',5'-Dichloro-3-(3,4,5-trifluorophenyl)propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.