Description

4'-Chloro-3'-Fluoro-3-(3,4,5-Trifluorophenyl)Propiophenone is a high-value fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to introduce specific halogenated and fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethylphenyl and halogenated propiophenone structures impart desired biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Acts as a fluorinated building block for creating advanced organic electronic materials, including liquid crystal display (LCD) components and organic light-emitting diode (OLED) emitters.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and tags used for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies in cross-coupling reactions, fluorination chemistry, and the construction of complex polycyclic systems.

Basic Information

Product Name	4'-Chloro-3'-Fluoro-3-(3,4,5-Trifluorophenyl)Propiophenone
CAS No.	898778-18-2
Molecular Formula	C15H7ClF4O
Molecular Weight	314.66 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-3-(3,4,5-trifluorophenyl)propan-1-one; 3',4',5'-Trifluoro-4-chloro-3-fluoropropiophenone; 3-(3,4,5-Trifluorophenyl)-1-(4-chloro-3-fluorophenyl)propan-1-one; 898778-18-2; 4-Chloro-3-fluoro-3'4'5'-trifluoropropiophenone; Propiophenone, 4'-chloro-3'-fluoro-3-(3,4,5-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3'-Fluoro-3-(3,4,5-Trifluorophenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.