Description

2'-Thiomethyl-3-(3,4,5-Trifluorophenyl)Propiophenone is a high-value, fluorinated aromatic ketone intermediate featuring a strategically positioned thiomethyl group. This compound is critical for the synthesis of advanced pharmaceutical and agrochemical active ingredients, where its unique trifluorophenyl moiety and sulfur-containing side chain enable precise molecular modifications. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used to develop advanced herbicides and fungicides, where the fluorine atoms contribute to improved lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a scaffold for constructing complex heterocyclic compounds in research laboratories.
• Fluorine Chemistry Research: An important substrate for studying the effects of polyfluorination on reaction kinetics and molecular conformation.

Basic Information

Product Name	2'-Thiomethyl-3-(3,4,5-Trifluorophenyl)Propiophenone
CAS No.	898777-82-7
Molecular Formula	C17H15F3OS
Molecular Weight	324.36 g/mol
Synonyms	1-[2-(Methylthio)phenyl]-3-(3,4,5-trifluorophenyl)propan-1-one; 3-(3,4,5-Trifluorophenyl)-1-[2-(methylthio)phenyl]propan-1-one; 2'-(Methylthio)-3-(3,4,5-trifluorophenyl)propiophenone; Propiophenone, 2'-(methylthio)-3-(3,4,5-trifluorophenyl)-; 898777-82-7; CAS 898777-82-7
EINECS	Contact for details

Quality Control

Our production of 2'-Thiomethyl-3-(3,4,5-Trifluorophenyl)Propiophenone adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.