Description

2'-Cyano-3-(3,4,5-trifluorophenyl)propiophenone is a high-value, fluorinated aromatic ketone intermediate with a reactive cyano group. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides that leverage the trifluorophenyl moiety for enhanced bioactivity and stability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its conjugated system and fluorine atoms.
• Organic Synthesis & Catalysis: Serves as a versatile substrate in cross-coupling reactions, cyano-group transformations, and fluorination studies.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and scale-up development.

Basic Information

Product Name	2'-Cyano-3-(3,4,5-trifluorophenyl)propiophenone
CAS No.	898777-70-3
Molecular Formula	C₁₆H₉F₃NO
Molecular Weight	288.25 g/mol
Synonyms	2-Cyano-1-(3,4,5-trifluorophenyl)-3-phenyl-1-propanone; 3-(3,4,5-Trifluorophenyl)-2-cyanopropiophenone; 1-Propanone, 2-cyano-1-(3,4,5-trifluorophenyl)-3-phenyl-; 2-Cyano-3-phenyl-1-(3,4,5-trifluorophenyl)propan-1-one; 898777-70-3; 2'-Cyano-3-(3,4,5-trifluorophenyl)propiophenone
EINECS	Contact for details

Quality Control

Our 2'-Cyano-3-(3,4,5-trifluorophenyl)propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.