Description

3'-Methoxy-3-(3,4,5-Trifluorophenyl)Propiophenone is a high-value fluorinated aromatic ketone intermediate of significant importance in modern synthetic chemistry. Its core value proposition lies in its precise molecular structure, which serves as a versatile building block for the synthesis of complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring fluorinated scaffolds to enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethylphenyl moiety can improve lipophilicity and target binding.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated monomers or ligands used in advanced polymers and catalysts.
• Organic Synthesis & Process Chemistry: Employed in academic and industrial R&D for method development, including cross-coupling reactions and carbonyl chemistry, due to its distinct electronic properties.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing processes.

Basic Information

Product Name	3'-Methoxy-3-(3,4,5-Trifluorophenyl)Propiophenone
CAS No.	898777-66-7
Molecular Formula	C16H13F3O2
Molecular Weight	294.27 g/mol
Synonyms	1-[3-(3,4,5-Trifluorophenyl)-1-oxopropyl]-3-methoxybenzene; 3-Methoxy-3'-(3,4,5-trifluorophenyl)propiophenone; 3'-Methoxy-3-(3,4,5-trifluorophenyl)-1-phenylpropan-1-one; Propiophenone, 3'-methoxy-3-(3,4,5-trifluorophenyl)-; 898777-66-7
EINECS	Contact for details

Quality Control

Our 3'-Methoxy-3-(3,4,5-Trifluorophenyl)Propiophenone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.