Description

4-Bromo-3-Fluoro-4'-Pyrrolidinomethyl Benzophenone is a high-value, multi-functional organic intermediate featuring a benzophenone core with strategically positioned bromo, fluoro, and pyrrolidinomethyl substituents. This compound matters for its role as a critical building block in advanced pharmaceutical and agrochemical synthesis, where its unique halogenated structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the halogenated benzophenone scaffold for bioactivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of photoaffinity labels or molecular probes for studying biological pathways.
• Organic Synthesis Building Block: A versatile reagent for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo substituent.
• Ligand Development: Potential precursor for creating novel ligands in catalytic systems for asymmetric synthesis.

Basic Information

Product Name	4-Bromo-3-Fluoro-4'-Pyrrolidinomethyl Benzophenone
CAS No.	898776-55-1
Molecular Formula	C18H17BrFNO
Molecular Weight	362.24 g/mol
Synonyms	4-Bromo-3-fluoro-4'-(pyrrolidin-1-ylmethyl)benzophenone; 1-({[4-(4-Bromo-3-fluorobenzoyl)phenyl]methyl})pyrrolidine; Benzophenone, 4-bromo-3-fluoro-4'-(pyrrolidinylmethyl)-; 898776-55-1; 4-Bromo-3-fluoro-4'-(N-pyrrolidinylmethyl)benzophenone; 4'-(Pyrrolidin-1-ylmethyl)-4-bromo-3-fluorobenzophenone
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluoro-4'-Pyrrolidinomethyl Benzophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects requiring material that meets stringent internal specifications or compendial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.