Description

4'-Chloro-2'-Fluoro-3-(4-Methoxyphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated and methoxy-substituted aromatic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D and manufacturing teams need this intermediate to develop and scale production of new drug candidates, relying on its consistent quality and reliable supply chain to ensure process integrity and final product efficacy.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug molecules, especially those targeting central nervous system (CNS) disorders and inflammatory conditions.
• API Synthesis: Used in constructing the core scaffold for potential APIs, where the chloro, fluoro, and methoxy functional groups are essential for biological activity and metabolic stability.
• Medicinal Chemistry Research: Employed in discovery labs for structure-activity relationship (SAR) studies and lead optimization processes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial drug substances.
• Fine Chemical Production: Acts as a specialized intermediate for synthesizing other complex, high-value fine chemicals and agrochemicals.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-3-(4-Methoxyphenyl)Propiophenone
CAS No.	898776-19-7
Molecular Formula	C₁₆H₁₄ClFO₂
Molecular Weight	292.73 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-(4-methoxyphenyl)propan-1-one; 3-(4-Methoxyphenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 4'-Chloro-2'-fluoro-3-(4-methoxyphenyl)propiophenone; 898776-19-7; 4-Chloro-2-fluoro-3'-(4-methoxyphenyl)propiophenone; Propiophenone, 4'-chloro-2'-fluoro-3-(4-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2'-Fluoro-3-(4-Methoxyphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon to maintain stability and prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.