Description

3',4'-Difluoro-3-(3-Methoxyphenyl)Propiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its precise molecular architecture, featuring difluoro and methoxyphenyl substituents, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients that require specific fluorine substitution patterns for enhanced bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms contribute to improved lipophilicity and target binding.
• Material Science Research: Serves as a monomer or building block for synthesizing specialized polymers and liquid crystals with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the creation of fluorinated probes and tags for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3',4'-Difluoro-3-(3-Methoxyphenyl)Propiophenone
CAS No.	898775-31-0
Molecular Formula	C16H14F2O2
Molecular Weight	276.28 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3-(3-methoxyphenyl)propan-1-one; 3-(3-Methoxyphenyl)-1-(3,4-difluorophenyl)propan-1-one; 3',4'-Difluoro-3-(3-methoxyphenyl)propiophenone; 898775-31-0; 3-(3-Methoxyphenyl)-1-(3,4-difluorophenyl)-1-propanone; Propiophenone, 3',4'-difluoro-3-(3-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-3-(3-Methoxyphenyl)Propiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for use in pharmaceutical development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.