Description

3,4-Difluoro-2'-Pyrrolidinomethyl Benzophenone is a high-value, fluorinated benzophenone derivative with a pyrrolidine side chain, serving as a critical building block in advanced organic synthesis. Its unique molecular architecture, combining fluorine atoms with a tertiary amine functional group, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily targeted at research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides where the difluoro and pyrrolidine groups contribute to target specificity and environmental persistence.
• Material Science Research: Serves as a precursor for photoactive polymers or advanced organic frameworks (MOFs/COFs) due to the benzophenone core.
• Chemical Biology Probes: Employed in the design of fluorinated probes and ligands for studying enzyme mechanisms and receptor binding.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring complex fluorinated intermediates.

Basic Information

Product Name	3,4-Difluoro-2'-Pyrrolidinomethyl Benzophenone
CAS No.	898775-06-9
Molecular Formula	C18H17F2NO
Molecular Weight	301.33 g/mol
Synonyms	(2-{[(3,4-Difluorophenyl)(phenyl)methyl]amino}ethyl)pyrrolidine; 1-[2-[[(3,4-Difluorophenyl)-phenyl-methyl]amino]ethyl]pyrrolidine; 3,4-Difluoro-2'-(pyrrolidin-1-ylmethyl)benzophenone; N-[(3,4-Difluorophenyl)(phenyl)methyl]-2-(pyrrolidin-1-yl)ethan-1-amine; Benzophenone, 3,4-difluoro-2'-(pyrrolidinylmethyl)-; 898775-06-9; CAS 898775-06-9
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2'-Pyrrolidinomethyl Benzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.