Description

4'-Chloro-3'-Fluoro-3-(3-Methoxyphenyl)Propiophenone is a high-purity fluorinated and chlorinated aromatic ketone, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its precise molecular architecture makes it an essential building block for synthesizing complex active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily required by R&D laboratories and production facilities in the pharmaceutical and agrochemical sectors for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the research and production of novel drug molecules, particularly in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the chloro-fluoro substitution pattern can enhance biological activity and stability.
• Organic Light-Emitting Diode (OLED) Materials Research: Acts as a precursor for electron-transport or host materials in organic electronics due to its aromatic structure.
• Liquid Crystal Intermediate: Serves as a building block in the synthesis of fluorinated liquid crystals for display technologies.
• Chemical Research & Development: A valuable reagent for academic and industrial chemists exploring new reactions and methodologies involving functionalized propiophenones.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	4'-Chloro-3'-Fluoro-3-(3-Methoxyphenyl)Propiophenone
CAS No.	898774-88-4
Molecular Formula	C16H14ClFO2
Molecular Weight	292.73 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-3-(3-methoxyphenyl)propan-1-one; 3-(3-Methoxyphenyl)-1-(4-chloro-3-fluorophenyl)propan-1-one; 4'-Chloro-3'-fluoro-3-(3-methoxyphenyl)propiophenone; 898774-88-4; Propiophenone, 4'-chloro-3'-fluoro-3-(3-methoxyphenyl)-; 1-(4-Chloro-3-fluorophenyl)-3-(3-methoxyphenyl)-1-propanone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3'-Fluoro-3-(3-Methoxyphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.