Description

3'-Fluoro-2-Pyrrolidinomethyl Benzophenone is a specialized fluorinated benzophenone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular architecture, which combines a benzophenone core with fluorinated and pyrrolidinyl substituents, enabling precise structural modifications in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules where fluorine introduction is a key strategy for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom to improve pesticidal activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Chemical Biology Probe Development: Serves as a scaffold for creating fluorescent tags, photoaffinity labels, and other molecular probes used in biochemical and cellular studies.
• Medicinal Chemistry SAR Studies: Facilitates structure-activity relationship (SAR) explorations by providing a versatile point for introducing the pyrrolidinomethyl moiety alongside fluorine substitution.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	3'-Fluoro-2-Pyrrolidinomethyl Benzophenone
CAS No.	898774-53-3
Molecular Formula	C18H18FNO
Molecular Weight	283.34 g/mol
Synonyms	2-[(2-Pyrrolidinyl)methyl]-3'-fluorobenzophenone; 3'-Fluoro-2-(pyrrolidin-2-ylmethyl)benzophenone; 1-[2-(3-Fluorobenzoyl)benzyl]pyrrolidine; (3-Fluorophenyl)[2-(pyrrolidin-2-ylmethyl)phenyl]methanone; 898774-53-3; 3'-Fluoro-2-pyrrolidin-2-ylmethylbenzophenone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-2-Pyrrolidinomethyl Benzophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and Good Manufacturing Practice (GMP) principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.