Description

3'-Azetidinomethyl-4-Bromo-3-Fluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecules targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those containing azetidine and benzophenone pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under GMP conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use in constructing linker components for bifunctional molecules due to its structural features.
• Kinase Inhibitor Synthesis: Intermediate in the preparation of compounds targeting various kinase enzymes, a major class of therapeutic agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized, non-commercial compounds for clinical trials.

Basic Information

Product Name	3'-Azetidinomethyl-4-Bromo-3-Fluorobenzophenone
CAS No.	898771-81-8
Molecular Formula	C17H15BrFNO
Molecular Weight	348.21 g/mol
Synonyms	4-Bromo-3-fluoro-3'-(azetidin-1-ylmethyl)benzophenone; 1-[(3-Benzoyl-4-bromo-2-fluorophenyl)methyl]azetidine; 3'-(Azetidin-1-ylmethyl)-4-bromo-3-fluorobenzophenone; (4-Bromo-3-fluorophenyl)[3-(azetidin-1-ylmethyl)phenyl]methanone; Azetidine, 1-[[3-(4-bromo-3-fluorobenzoyl)phenyl]methyl]-; 898771-81-8; 3'-Azetidin-1-ylmethyl-4-bromo-3-fluorobenzophenone
EINECS	Contact for details

Quality Control

Our 3'-Azetidinomethyl-4-Bromo-3-Fluorobenzophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.