Description

3-(3,4,5-Trifluorobenzoyl)Thiophene is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its core value lies in providing a trifluoromethyl-substituted benzoyl moiety, which is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated aromatic structures.
• Chemical Research: Employed in academic and industrial laboratories for method development, catalysis studies, and exploring novel heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of complex molecules for clients in life sciences and advanced materials.

Basic Information

Product Name	3-(3,4,5-Trifluorobenzoyl)Thiophene
CAS No.	898771-66-9
Molecular Formula	C11H5F3OS
Molecular Weight	248.22 g/mol
Synonyms	3-(3,4,5-Trifluorobenzoyl)thiophene; Thiophen-3-yl(3,4,5-trifluorophenyl)methanone; 3,4,5-Trifluorophenyl 3-thienyl ketone; (3,4,5-Trifluorophenyl)(thiophen-3-yl)methanone; 898771-66-9; 3-TFBT
EINECS	Contact for details

Quality Control

Our 3-(3,4,5-Trifluorobenzoyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.