Description

2'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its precise molecular framework serves as a key building block. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Development: Serves as a critical raw material for scaling up API manufacturing processes from laboratory to pilot and commercial scale.
• Custom Synthesis: Employed by fine chemical companies for the contract manufacturing of specialized, high-value intermediates for the pharmaceutical industry.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	2'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone
CAS No.	898770-39-3
Molecular Formula	C₁₆H₁₄ClFO₂
Molecular Weight	292.73 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one; 3-(2-Methoxyphenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 2'-Chloro-4'-fluoro-3-(2-methoxyphenyl)propiophenone; Propiophenone, 2'-chloro-4'-fluoro-3-(2-methoxyphenyl)-; CAS 898770-39-3
EINECS	Contact for details

Quality Control

Our 2'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting full compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.