Description

3'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate with a defined chiral center, crucial for the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in providing a structurally sophisticated building block that enables efficient, multi-step synthetic routes in modern medicinal chemistry. This compound is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries focused on developing new therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a critical precursor in the multi-step production of novel pharmaceutical compounds, particularly those targeting central nervous system (CNS) disorders.
• Chiral Building Block: Used in asymmetric synthesis to introduce specific stereochemistry required for biologically active molecules, ensuring high enantiomeric purity in the final API.
• Medicinal Chemistry Research: Employed in drug discovery programs for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes from laboratory scale to commercial manufacturing, focusing on yield, purity, and cost-effectiveness.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke intermediates for client-specific drug development projects.

Basic Information

Product Name	3'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone
CAS No.	898770-18-8
Molecular Formula	C16H14ClFO2
Molecular Weight	292.73 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one; 3-(2-Methoxyphenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one; 3'-Chloro-4'-fluoro-3-(2-methoxyphenyl)propiophenone; 898770-18-8; Propiophenone, 3'-chloro-4'-fluoro-3-(2-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Chloro-4'-Fluoro-3-(2-Methoxyphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets exacting standards for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.